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Cifrotil (Ciprofloxacin 500 mg)
For the use only of a Registered Medical Practitioner or a Hospital or a Laboratory.



Each film coated tablet contains
Ciprofloxacin Hydrochloride USP equivalent to Ciprofloxacin 500 mg.


CIFROTIL has a unique mode of action. It blocks both subunits of DNA gyrase and disrupts DNA functions leading to the death of bacteria. The total destruction of bacterial DNA by CIFROTIL does not allow the emergence of plasmids. Ciprofloxacin does not promote plasmid-borne resistance and rapidly eliminates R plasmids. Chromosomal mutation is also rare. Ciprofloxacin exerts a unique post-antibiotic effect for a prolonged period (exceeding 4 hours). Thus, it continues to prevent bacteria from rapid re-growth even when the concentrations are below the MICs.


CIFROTIL is active against E.coli, Klebsiella, Proteus, Salmonella and Shigella spp., enteropathogenic E.coli, Y.enterocolitica, V.cholerae, Pseudomonas aeruginosa, N.gonorrhoeae, H.influenzae, I , -N.Menii,yiYJis,-Staphgiococcur aurens; --Streptoeeeeus -pyogenes, Streptococcus pneumoniae, Staphylococcus epidermidis, Listeria monocytogenes and otherorganisms.


Respiratory tract infections, eg. pneumonia, bronchopneumonia, infected pleurisy, empyema, lung abscess, infected bronchiectasis, acute exacerbation of chronic bronchitis.
Ear, nose and throat infections, eg. otitis media, sinusitis, mastoiditis.
Urinary tract infections, eg. acute and chronic pyelonephritis, prostatitis, cystitis, epididymitis.
Gonorrhoeae, skin and soft tissue infections, gastrointestinal tract infections, and typhoid and paratyphoid fever.
Intraabdominal, gynaecological, bone and joint, severe systemic and surgical infections.

Dosage & Administration

Uncomplicated Urinary Tract infection : 250 mg.
Prostatitis and Complicated urinary tract infection: 500 mg.
Lower Respiratory tract infection: 500 mg.
Ear, Nose and Throat infections : 500-750 mg.
Bone and Joint Infections 500-750 mg.
Gastroenteritis : 250-500 mg.
Enteric fever : 500 mg. for 10-14 days.
Gonorrhoeae : 250 mg. as single dose.

All doses to be taken every 12 hrs.

Ciprofloxacin is not recommended in children up to 18 years. However, it may be given to children at doses of 10-20mg (base)/kg body weight every 12 hrs when alternative therapy cannot be used.


History of hypersensitivity to Ciprofloxacin or any other quinolone derivatives.


If concomitant use cannot be avoided, serum levels of Theophylline should be monitored and dosage adjusted.


Use cautiously in patients with CNS disorders, eg. Severe cerebral arteriosclerosis or epilepsy. The patients should be well hydrated to prevent crystalluria. The dose should be reduced inpatients with renal impairment. Side Effects: Diarrhoea, vomiting, abdominal pain, headache and rash have been reported. Other rare side effects have also been reported.


Patients should be monitored for signs of Theophylline toxicity during concurrent use and dosage adjustments should be made. Probenecid delays excretion of Ciprofloxacin. The absorption of Ciprofloxacin is delayed when antacids eg. Magnesium hydroxide and / or Aluminium hydroxide are given simultaneously.


Blister of 10 tablets. 10 such blisters in a carton.


Store in a cool, dry place.

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